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機能的超音波検査×PET動態モデリング×
分野医用画像医用画像
系統Process / pipelineProcess / pipeline
提唱年20111983
提唱者Mickael TanterChristoph Patlak
種類High-framerate doppler imaging for hemodynamicsMathematical framework for tracer kinetics in PET imaging
原典Macé, E., Montaldo, G., Trenholm, S., et al. (2011). Functional ultrasound imaging of the brain. Nature Methods, 8(8), 662-664. DOI ↗Patlak, C. S., Blasberg, R. G., Fenstermacher, J. D. (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Journal of Cerebral Blood Flow & Metabolism, 3(1), 1-7. DOI ↗
別名fUS, doppler ultrasound, ultrafast ultrasoundPET pharmacokinetics, Dynamic PET, PET compartmental modeling
関連55
概要Functional Ultrasound (fUS) is a high-framerate Doppler ultrasound technique that dynamically maps blood flow and hemodynamic changes in vivo with millisecond temporal resolution. Pioneered by Tanter, Macé, and colleagues in the 2010s, fUS enables real-time imaging of microvascular perfusion in the brain and other organs. By combining ultrafast acquisition (1000-5000 frames per second) with Doppler processing, fUS reveals functional activity (hemodynamic changes during stimulation or behavior) and vascular networks with unprecedented spatiotemporal detail.PET kinetic modeling is a quantitative analysis technique that tracks the temporal behavior of radioactive tracers in tissue to extract physiological parameters such as blood flow, metabolic rate, and receptor density. Established by Patlak, Logan, and Gunn in the 1980s and 1990s, kinetic modeling transforms raw PET time-activity curves into interpretable biological measures. It is widely used in neurology, oncology, and cardiology to assess disease severity, treatment response, and regional tissue function.
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ScholarGate手法を比較: Functional Ultrasound · PET Kinetic Modeling. 2026-06-19に以下より取得 https://scholargate.app/ja/compare