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| カラムクロマトグラフィー× | 合成経路計画× | |
|---|---|---|
| 分野 | 化学 | 化学 |
| 系統 | Process / pipeline | Process / pipeline |
| 提唱年≠ | 1903 | 1969 |
| 提唱者≠ | Mikhail Tsvet | Elias James Corey |
| 種類≠ | Chromatographic separation technique | Strategic planning methodology |
| 原典≠ | Skoog, D. A., Holler, F. J., & Crouch, S. R. (2017). Principles of Instrumental Analysis (7th ed.). Cengage Learning. ISBN: 978-1305577213 | Corey, E. J., & Cheng, X. M. (1991). The Logic of Chemical Synthesis. John Wiley & Sons. ISBN: 978-0471096092 |
| 別名≠ | liquid chromatography, column liquid chromatography | retrosynthesis, retrosynthetic analysis, synthetic route design |
| 関連 | 3 | 3 |
| 概要≠ | Column chromatography is a liquid separation technique in which a stationary phase (typically silica gel or alumina) is packed into a vertical column, and a mobile phase (solvent) percolates through it to separate mixture components. Pioneered by Mikhail Tsvet in 1903, column chromatography remains the workhorse of organic chemistry laboratories for purifying reaction products and isolating target compounds. | Synthesis route planning, grounded in retrosynthetic analysis, is a strategic approach to designing efficient chemical syntheses. Formalized by Elias James Corey in the 1960s (earning him the Nobel Prize in 1990), this methodology systematically deconstructs target molecules into simpler precursors and starting materials, enabling chemists to discover logical, economical, and practical synthesis routes. |
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