手法を比較

	適応的無作為化比較試験	多群実験
分野	実験計画法	実験計画法
系統	Process / pipeline	Process / pipeline
提唱年	1980s–2000s (formalized; earlier sequential testing roots from Wald, 1947)	1990s–2000s (clinical formalization); multi-arm concept implicit in ANOVA-era factorial designs
提唱者	Donald Berry and others; foundational adaptive trial methods developed through 1980s–2000s biostatistics literature	Developed within clinical trials methodology; formalized by Parmar, Royston and colleagues (UK MRC CTU, early 2000s)
種類	Experimental design — adaptive variant of RCT	Experimental design
原典	Chow, S.-C., & Chang, M. (2008). Adaptive Design Methods in Clinical Trials. Chapman & Hall/CRC. ISBN: 978-1584887690	Royston, P., Parmar, M. K. B., & Qian, W. (2003). Novel designs for multi-arm clinical trials with survival outcomes with an application in ovarian cancer. Statistics in Medicine, 22(14), 2239–2256.
別名	Adaptive RCT, Response-adaptive RCT, Adaptive clinical trial, Platform trial	multi-arm trial, multiple-arm experiment, multi-group experiment, many-arm design
関連	6	5
概要	An adaptive randomized controlled trial (adaptive RCT) is an experimental design in which pre-specified rules allow modifications to the trial while it is ongoing — such as changing allocation ratios, dropping underperforming arms, or stopping early for efficacy or futility — based on accumulating interim data. These adaptations are planned before the trial starts and governed by statistical rules to preserve Type I error control and validity.	A multi-arm experiment simultaneously compares three or more treatment or intervention conditions — each called an arm — against a shared control or against one another. By testing multiple alternatives in a single study, it yields more information per participant than running separate two-group experiments sequentially, while controlling the overall Type I error rate through pre-specified comparison strategies.