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| Disegno caso-incrocio prospettico× | Studio Caso-Controllo× | |
|---|---|---|
| Campo | Epidemiologia | Epidemiologia |
| Famiglia | Process / pipeline | Process / pipeline |
| Anno di origine≠ | 1991 (base design); prospective variant described in late 1990s–2000s | 1950s (formal methodology); precursors in the 1920s |
| Ideatore≠ | Malcolm Maclure (case-crossover concept); prospective variant established by subsequent methodologists including Navidi and Weinhandl | Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s |
| Tipo≠ | Observational epidemiological study design | Observational analytic study design |
| Fonte seminale≠ | Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ | Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860 |
| Alias | prospective case-crossover study, forward-looking case-crossover, prospective self-controlled case-crossover, real-time case-crossover | case-referent study, case-control design, retrospective case-control, case-control analysis |
| Correlati≠ | 3 | 6 |
| Sintesi≠ | The prospective case-crossover design is an observational epidemiological study in which each case serves as their own control. Unlike the retrospective variant, exposures are recorded in real time as participants are followed forward, eliminating recall bias. It is particularly suited to investigating transient environmental or behavioral triggers of acute events such as myocardial infarction, asthma attacks, or road-traffic injuries. | A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses. |
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