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| Esperimento fattoriale frazionario pragmatico× | Trial Controllato Randomizzato (RCT)× | |
|---|---|---|
| Campo | Disegno sperimentale | Disegno sperimentale |
| Famiglia≠ | Process / pipeline | Hypothesis test |
| Anno di origine≠ | Fractional factorial designs: 1940s–1950s; pragmatic application: 2000s–2010s | 1948 |
| Ideatore≠ | Building on Fisher (1935); pragmatic adaptation by Collins, Murphy & Strecher (2007) via MOST framework | James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948) |
| Tipo≠ | Experimental design | Interventional comparative study |
| Fonte seminale≠ | Collins, L. M., Murphy, S. A., & Strecher, V. (2007). The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): New methods for more potent eHealth interventions. American Journal of Preventive Medicine, 32(5S), S112–S118. DOI ↗ | Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332. DOI ↗ |
| Alias | pragmatic FFE, fractional factorial trial, pragmatic factorial design, FFD in pragmatic settings | RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı |
| Correlati≠ | 4 | 7 |
| Sintesi≠ | A pragmatic fractional factorial experiment applies fractional factorial design principles to real-world or clinical intervention research, enabling simultaneous evaluation of multiple intervention components in a resource-efficient fraction of the full factorial runs. Popularised through the Multiphase Optimization Strategy (MOST), it identifies which components of a multi-component intervention contribute meaningfully to outcomes before a confirmatory randomized trial is conducted. | A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010). |
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