Confronta i metodi
Esamina i metodi selezionati fianco a fianco; le righe che differiscono sono evidenziate.
| Trial Clinico Randomizzato Meta-analitico× | Trial Controllato Randomizzato (RCT)× | |
|---|---|---|
| Campo≠ | Epidemiologia | Disegno sperimentale |
| Famiglia≠ | Process / pipeline | Hypothesis test |
| Anno di origine≠ | 1976 (Glass coinage of meta-analysis); 1993 (Cochrane Collaboration formalization) | 1948 |
| Ideatore≠ | Gene V. Glass (meta-analysis method); Cochrane Collaboration (systematic RCT pooling standards) | James Lind (early precursor, 1747); modern formulation: Austin Bradford Hill & Medical Research Council (1948) |
| Tipo≠ | Quantitative evidence-synthesis design | Interventional comparative study |
| Fonte seminale≠ | Higgins, J. P. T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M. J., & Welch, V. A. (Eds.). (2019). Cochrane Handbook for Systematic Reviews of Interventions (2nd ed.). Wiley-Blackwell. ISBN: 978-1119536628 | Schulz, K.F., Altman, D.G., Moher, D., for the CONSORT Group (2010). CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMJ, 340, c332. DOI ↗ |
| Alias | meta-analytic RCT, MA-RCT, meta-analysis of RCTs, pooled randomized trial analysis | RCT, randomised controlled trial, clinical trial, Randomize Kontrollü Çalışma (RCT) Tasarımı |
| Correlati≠ | 3 | 7 |
| Sintesi≠ | A meta-analytic randomized clinical trial is a formal evidence-synthesis method that identifies, appraises, and statistically combines the results of multiple randomized clinical trials addressing the same clinical question. By pooling trial-level data, it produces a single, more precise estimate of treatment effect and quantifies between-trial heterogeneity, sitting at the apex of the evidence hierarchy for evaluating healthcare interventions. | A randomized controlled trial (RCT) is the gold standard experimental design in clinical and health research, in which participants are randomly allocated to a treatment group or a control group so that the effect of an intervention can be measured with the highest possible degree of internal validity. The modern parallel-group RCT was formalized by Austin Bradford Hill and the Medical Research Council in their landmark streptomycin trial of 1948, and its reporting is governed today by the CONSORT 2010 guidelines (Schulz et al., 2010). |
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