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| Disegno caso-incrocio meta-analitico× | Disegno Caso-Incrociato× | |
|---|---|---|
| Campo | Epidemiologia | Epidemiologia |
| Famiglia | Process / pipeline | Process / pipeline |
| Anno di origine≠ | 1991 (base design); meta-analytic applications from late 1990s onward | 1991 |
| Ideatore≠ | Maclure (case-crossover basis, 1991); meta-analytic extension through environmental epidemiology consortia (1990s–2000s) | Malcolm Maclure |
| Tipo≠ | Observational epidemiological design with meta-analytic synthesis | Observational epidemiological study design |
| Fonte seminale | Maclure, M. (1991). The case-crossover design: a method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ | Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. DOI ↗ |
| Alias | pooled case-crossover analysis, case-crossover meta-analysis, MACCO, systematic pooling of case-crossover studies | case-crossover study, CCO design, self-matched case study, within-person crossover case study |
| Correlati | 3 | 3 |
| Sintesi≠ | The meta-analytic case-crossover design combines the within-person control structure of the case-crossover study with formal meta-analytic pooling across multiple studies. Each contributing study uses cases as their own controls by comparing exposure windows immediately preceding an acute event to matched reference windows in the same individual. The pooled approach synthesizes conditional odds ratios across studies, maximizing statistical power and generalizability — commonly applied to short-term environmental exposures such as air pollution, temperature extremes, and drug triggers of acute events. | The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury. |
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