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	Questionario sulla Consapevolezza dell'Ipoglicemia di Clarke	ThyPRO: Scala per gli Esiti Riportati dai Pazienti Relativi alla Tiroide
Campo	Endocrinologia	Endocrinologia
Famiglia	Process / pipeline	Process / pipeline
Anno di origine	1995	2009
Ideatore	William L. Clarke, Don J. Cox, Lois A. Gonder-Frederick	Torquil Watt, Jens Bjørner, Marianne Groenvold
Tipo	Patient self-report questionnaire	Patient self-report questionnaire
Fonte seminale	Clarke, W. L., Cox, D. J., Gonder-Frederick, L. A., Julian, D., Schlundt, D., & Polonsky, W. (1995). Reduced awareness of hypoglycemia in adults with IDDM: A prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care, 18(6), 517-522.	Watt, T., Bjorner, J. B., Groenvold, M., et al. (2009). Establishing construct validity for the thyroid-related patient reported outcomes (ThyPRO): An initial examination. J Clin Endocrinol Metab, 94(9), 3572-3580.
Alias	HAQ, Clarke HAQ, Hypoglycemia Awareness Scale	ThyPRO-85, ThyPRO-39
Correlati	3	3
Sintesi	The Clarke Hypoglycemia Awareness Questionnaire is an 8-item instrument designed to identify patients with impaired hypoglycemia awareness—a condition in which diabetic patients fail to perceive early warning symptoms of low blood glucose, substantially increasing their risk of severe hypoglycemia. Developed by Clarke and colleagues in 1995, it is the most widely used screening tool for this dangerous complication in type 1 diabetes and in insulin-treated type 2 diabetes populations.	ThyPRO is a comprehensive patient-reported outcome measure assessing the quality of life impact of thyroid disease and its treatment across 13 dimensions. Developed by Watt and colleagues in 2009, it is the most extensively validated thyroid-specific instrument, covering both physical and psychological domains relevant to patients with hyperthyroidism, hypothyroidism, and thyroid cancer.