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	Scala di Valutazione della Depressione di Hamilton (HAM-D)	Scala di Valutazione della Depressione di Montgomery-Åsberg (MADRS)
Campo	Psicologia clinica	Psicologia clinica
Famiglia	Process / pipeline	Process / pipeline
Anno di origine	1960	1979
Ideatore	Max Hamilton	Stuart Montgomery & Marie Åsberg
Tipo	Clinician-rated interview scale	Clinician-rated interview scale
Fonte seminale	Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery & Psychiatry, 23(1), 56–62.	Montgomery, S. A., & Åsberg, M. (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.
Alias	HAM-D, HDRS, Hamilton Rating Scale for Depression	MADRS, Montgomery-Asberg Depression Rating Scale
Correlati	5	5
Sintesi	The Hamilton Depression Rating Scale, published by Max Hamilton in 1960, is a clinician-administered interview assessment of depressive symptom severity. The most common version contains 17 items (HAM-D-17), though 21-item and 24-item versions exist. It is considered the gold standard outcome measure in antidepressant drug trials and remains the most cited depression rating scale in the psychiatric literature. Unlike self-report measures, HAM-D requires clinician judgment and observation, making it particularly valuable in research settings where standardized measurement by trained raters is essential.	The Montgomery-Åsberg Depression Rating Scale is a 10-item clinician-rated assessment designed by Stuart Montgomery and Marie Åsberg in 1979 to measure depression severity and track treatment response. Published in the British Journal of Psychiatry, the MADRS was developed as an alternative to longer instruments like the Hamilton Depression Rating Scale, emphasizing items most sensitive to treatment change. It has become a primary outcome measure in antidepressant trials and is widely used in both research and clinical practice across psychiatry, primary care, and medical specialty settings.