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	Valutazione Globale del Medico sull'Attività del Lupus (PGA)	Indice di Attività di Malattia del Lupus Eritematoso Sistemico 2000 (SLEDAI-2K)
Campo	Reumatologia	Reumatologia
Famiglia	Process / pipeline	Process / pipeline
Anno di origine	1992	2002
Ideatore	Bombardier et al.	Gladman et al.
Tipo	Clinician-rated	Clinician-rated
Fonte seminale	Petri M. Thermodynamic instability in the pathogenesis of lupus nephritis. Nat Rev Rheum. 2016;12(11):635-642.	Gladman DD, Ibañez D, Urowitz MB. Systemic Lupus Erythematosus Disease Activity Index 2000. The Journal of Rheumatology. 2002;29(2):288-291.
Alias	Physician Global Assessment, PGA-Lupus, Clinician Global Assessment-SLE	SLEDAI, SLEDAI-2K, SLE Disease Activity Index
Correlati	3	3
Sintesi	The Physician Global Assessment (PGA) is a clinician-rated, single-item measure of overall systemic lupus erythematosus (SLE) disease activity on a visual analogue scale (0–10). Used alongside structured indices like SLEDAI, PGA captures the clinician's integrated judgment of SLE severity, synthesising clinical examination, serology, imaging, and organ-specific findings into a holistic activity score. PGA is simple, practical, and widely used in SLE research and clinical practice as a complementary measure that reflects experienced clinician assessment of disease state.	The SLEDAI is a comprehensive clinician-assessed measure of systemic lupus erythematosus (SLE) disease activity, capturing manifestations across multiple organ systems (cutaneous, renal, neuropsychiatric, hematologic, and serological). Introduced by Bombardier et al. (1992) and refined as SLEDAI-2K by Gladman et al. (2002), SLEDAI uses weighted scoring of 24 clinical and laboratory features to quantify overall SLE activity. It is the most widely used outcome measure in SLE research and clinical trials, enabling standardised assessment of disease progression, flare prediction, and treatment response in this complex multisystem disease.