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| EDSS: Scala Kurtzke Espansa di Valutazione della Disabilità× | MSFC: Multiple Sclerosis Functional Composite× | |
|---|---|---|
| Campo | Neurologia | Neurologia |
| Famiglia | Process / pipeline | Process / pipeline |
| Anno di origine≠ | 1983 | 1999 |
| Ideatore≠ | John F. Kurtzke | Gary Cutter, Richard Rudick, and NMSS Consortium |
| Tipo≠ | Clinician-rated | Clinician-administered performance test |
| Fonte seminale≠ | Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33(11), 1444-1452. DOI ↗ | Cutter, G. R., Baier, M. L., Rudick, R. A., et al. (1999). Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Multiple Sclerosis, 5(4), 244-250. DOI ↗ |
| Alias | Expanded Disability Status Scale | MS Functional Composite |
| Correlati | 4 | 4 |
| Sintesi≠ | The EDSS is the most widely used clinical disability rating scale in multiple sclerosis research and practice. Developed by John Kurtzke in 1983, it provides a 0-10 ordinal scale capturing disease severity across eight neurological functional systems and functional status. The EDSS remains the primary endpoint in MS clinical trials and longitudinal cohort studies, with decades of prognostic and comparative data worldwide. | The Multiple Sclerosis Functional Composite (MSFC) is an objective, performance-based assessment of MS-related disability capturing three key functional domains: lower extremity mobility, upper extremity coordination, and cognitive/processing speed. Developed in 1999 by the National MS Society and adopted widely in clinical trials, the MSFC provides quantifiable endpoints complementing the Expanded Disability Status Scale (EDSS). The three-component design addresses EDSS limitations by including cognition and standardizing measurement via timed tasks. |
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