Confronta i metodi
Esamina i metodi selezionati fianco a fianco; le righe che differiscono sono evidenziate.
| Esperimento Adattivo Randomizzato a Cluster× | Trial Controllato Randomizzato a Blocchi× | |
|---|---|---|
| Campo | Disegno sperimentale | Disegno sperimentale |
| Famiglia | Process / pipeline | Process / pipeline |
| Anno di origine≠ | 2000s–2010s | 1920s (Fisher's blocking principle); applied to RCTs from the 1940s onward |
| Ideatore≠ | Synthesised from cluster randomization methodology (Donner, 1978; Donner & Klar, 2000) and adaptive design frameworks (Bauer & Kohne, 1994; Pallmann et al., 2018) | R. A. Fisher (blocking principle); systematic RCT application by Bradford Hill and later Pocock, Friedman et al. |
| Tipo | Experimental design | Experimental design |
| Fonte seminale≠ | Hayes, R. J., & Moulton, L. H. (2017). Cluster Randomised Trials (2nd ed.). CRC Press / Chapman & Hall. ISBN: 978-1498728225 | Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2010). Fundamentals of Clinical Trials (4th ed.). Springer. ISBN: 978-1441915856 |
| Alias | adaptive cluster RCT, adaptive group-randomized trial, cluster adaptive design, adaptive cluster trial | blocked RCT, block-randomized trial, stratified block randomization trial, permuted block randomization |
| Correlati | 5 | 5 |
| Sintesi≠ | A cluster randomized adaptive experiment combines two methodological principles: (1) intact groups such as schools, clinics, or villages are randomly assigned to treatment conditions rather than individuals, and (2) pre-specified rules allow the design to be modified during the trial based on accumulating cluster-level data. Adaptations may include dropping underperforming arms, reallocating clusters, or adjusting sample size, while maintaining statistical validity and controlling Type I error. | A blocked randomized controlled trial (blocked RCT) uses permuted-block randomization to ensure that treatment groups remain balanced in size — and optionally in key characteristics — throughout recruitment. Within each block of fixed or randomly varied size, all treatment allocations are present in equal numbers, so imbalance cannot accumulate even if the trial is stopped early. This makes blocked RCTs the standard randomization approach in clinical and behavioral intervention research. |
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