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	Punteggio CHA₂DS₂-VASc	Punteggio APACHE II	Punteggio di Wells per la TVP
Campo	Valutazione clinica	Valutazione clinica	Valutazione clinica
Famiglia	Process / pipeline	Process / pipeline	Process / pipeline
Anno di origine	2010	1985	1994
Ideatore	Gregory Y. H. Lip, Robby Nieuwlaat, et al.	William A. Knaus, et al.	Philip S. Wells
Tipo	Atrial fibrillation stroke risk stratification	ICU severity and mortality prediction	Venous thromboembolism risk stratification
Fonte seminale	Lip, G. Y., Nieuwlaat, R., Pisters, R., Lane, D. A., & Crijns, H. J. (2010). Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest, 137(2), 263-272.	Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985). APACHE II: a severity of disease classification system. Critical Care Medicine, 13(10), 818-829.	Wells, P. S., Hirsh, J., Anderson, D. R., et al. (1994). A simple clinical model for the diagnosis of deep-vein thrombosis combined with impedance plethysmography. Archives of Internal Medicine, 154(13), 1541-1546.
Alias	CHA2DS2VASc, Atrial fibrillation stroke risk	APACHE-II, APACHE2	Wells DVT Score, DVT Wells
Correlati	3	3	3
Sintesi	The CHA₂DS₂-VASc score, developed by Lip, Nieuwlaat, and colleagues in 2010, is a 9-point risk stratification tool for predicting annual stroke and systemic thromboembolism risk in patients with atrial fibrillation. It is the recommended score by major cardiology guidelines for guiding anticoagulation decisions.	The Acute Physiology and Chronic Health Evaluation (APACHE) II score, introduced by Knaus et al. in 1985, is a 71-point severity of illness classification system for critically ill patients. It combines acute physiological parameters, age, and chronic health status to predict intensive care unit (ICU) mortality, facilitating patient risk stratification and research standardization.	The Wells score, developed by Wells et al. in 1994, is a clinical prediction rule that stratifies patients into low, intermediate, or high pretest probability of deep vein thrombosis (DVT). It combines seven clinical features to guide diagnostic testing decisions and reduce unnecessary imaging in suspected DVT patients.