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	Punteggio APACHE II	Punteggio qSOFA	Punteggio Sequential Organ Failure Assessment
Campo	Valutazione clinica	Valutazione clinica	Valutazione clinica
Famiglia	Process / pipeline	Process / pipeline	Process / pipeline
Anno di origine	1985	2016	1996
Ideatore	William A. Knaus, et al.	Sepsis-3 Taskforce	Jean-Louis Vincent and Rui Moreno
Tipo	ICU severity and mortality prediction	Rapid sepsis screening	Organ dysfunction and sepsis assessment
Fonte seminale	Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985). APACHE II: a severity of disease classification system. Critical Care Medicine, 13(10), 818-829.	Singer, M., Deutschman, C. S., Seymour, C. W., et al. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315(8), 801-810.	Vincent, J. L., Moreno, R., Takala, J., et al. (1996). The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfuncti on/failure. Intensive Care Medicine, 22(7), 707-710.
Alias	APACHE-II, APACHE2	Quick SOFA, qSOFA	SOFA, Sepsis-related Organ Failure Assessment
Correlati	3	3	3
Sintesi	The Acute Physiology and Chronic Health Evaluation (APACHE) II score, introduced by Knaus et al. in 1985, is a 71-point severity of illness classification system for critically ill patients. It combines acute physiological parameters, age, and chronic health status to predict intensive care unit (ICU) mortality, facilitating patient risk stratification and research standardization.	The Quick Sequential Organ Failure Assessment (qSOFA) score, introduced by the Sepsis-3 taskforce in 2016, is a rapid 3-variable bedside screening tool for identifying non-ICU patients at high risk of sepsis-related mortality. It uses altered mentation, systolic hypotension, and tachypnea to quickly stratify patients without requiring laboratory testing.	The Sequential Organ Failure Assessment (SOFA) score, introduced by Vincent and Moreno in 1996, is a 24-point daily assessment tool that quantifies organ dysfunction across six physiological systems in critically ill patients. It was adopted into the 2016 Sepsis-3 definitions and is now the international standard for identifying and grading sepsis-related organ failure.