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मेटा-एनालिटिक सर्वाइवल एनालिसिस×कॉक्स प्रोपोर्शनल हैज़र्ड्स×
क्षेत्रमहामारी विज्ञानमहामारी विज्ञान
परिवारProcess / pipelineProcess / pipeline
उद्भव वर्ष1990s–2000s (formalized ~1998)1972
प्रवर्तकParmar, Torri & Stewart (statistical framework); broader IPD tradition developed by the Early Breast Cancer Trialists' Collaborative GroupSir David Roxbee Cox
प्रकारQuantitative synthesis / meta-analytic methodSemi-parametric regression model
मौलिक स्रोतParmar, M. K. B., Torri, V., & Stewart, L. (1998). Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine, 17(24), 2815–2834. DOI ↗Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. DOI ↗
उपनामmeta-analysis of time-to-event data, pooled survival analysis, IPD survival meta-analysis, aggregate survival meta-analysisCox regression, Cox PH model, proportional hazards model, CPH
संबंधित45
सारांशMeta-analytic survival analysis is a quantitative synthesis method that pools hazard ratios and related time-to-event statistics from multiple independent studies to produce a single, more precise estimate of a treatment or exposure effect on survival outcomes such as overall survival, disease-free survival, or time to relapse. It can operate on aggregate published data or on individual patient data (IPD) contributed directly by study investigators.The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.
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