השוואת שיטות

	מודל סיכונים מותאמי סיכון של קוקס	מבחן לוג-רנְק להשוואת עקומות הישרדות
תחום	אפידמיולוגיה	הישרדות
משפחה	Process / pipeline	Survival analysis
שנת המקור	1972 (Cox model); risk adjustment widespread from 1980s	1966
הוגה השיטה	D. R. Cox (base model); risk-adjustment as routine practice formalised through clinical epidemiology literature from the 1980s onward	Mantel, N.
סוג	Multivariable survival regression	Non-parametric hypothesis test
מקור מכונן	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.	Mantel, N. (1966). Evaluation of Survival Data and Two New Rank Order Statistics Arising in Its Consideration. Cancer Chemotherapy Reports, 50(3), 163–170.
כינויים	adjusted Cox regression, multivariable Cox model, covariate-adjusted survival analysis, risk-adjusted survival model	Mantel log-rank test, Mantel-Cox test, log-rank sağkalım testi, Log-Rank Testi
קשורות	5	2
תקציר	Risk-adjusted Cox proportional hazards regression extends the classical Cox (1972) survival model by simultaneously entering known confounders — age, sex, comorbidities, disease severity — into the model alongside the exposure of primary interest. This adjustment isolates the independent effect of the exposure on the hazard of an event, producing hazard ratios (HRs) that are not distorted by baseline differences between comparison groups. It is the most widely used method for multivariable survival analysis in clinical and epidemiological research.	The log-rank test, developed by Nathan Mantel in 1966, is a non-parametric hypothesis test that compares the overall survival experience of two or more groups throughout the entire follow-up period. It is the standard companion to Kaplan-Meier curves and determines whether observed differences between curves are statistically meaningful.