השוואת שיטות

	מבחן מקדונלד-קרייטמן	מבחן HKA
תחום	גנטיקה	גנטיקה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1991	1987
הוגה השיטה	James McDonald & Martin Kreitman	Richard Hudson, Martin Kreitman & Montserrat Aguade
סוג	Hypothesis test	Statistical test
מקור מכונן	McDonald, J. H., & Kreitman, M. (1991). Adaptive protein evolution at the Adh locus in Drosophila. Nature, 351(6328), 652–654.	Hudson, R. R., Kreitman, M., & Aguadé, M. (1987). A test of neutral molecular evolution based on nucleotide data. Genetics, 116(1), 153–159.
כינויים	MK test, Positive selection test	HKA test, Polymorphism divergence test
קשורות	4	4
תקציר	The McDonald-Kreitman (MK) test is a statistical method for detecting adaptive evolution by comparing ratios of synonymous and nonsynonymous substitutions within and between species. Developed by James McDonald and Martin Kreitman in 1991, this test exploits the key insight that neutral mutations accumulate at similar rates within and between species, while adaptive (nonsynonymous) substitutions should be enriched between species if they have been fixed by positive selection. The MK test has become a standard tool in molecular evolutionary biology for identifying genes under natural selection.	The Hudson-Kreitman-Aguade (HKA) test is a statistical method that tests for neutral evolution by comparing levels of within-population polymorphism and between-population divergence at multiple loci. Developed by Hudson, Kreitman, and Aguade in 1987, this test uses the principle that neutral loci should show expected relationships between polymorphism and divergence. Loci deviating from these relationships are candidates for selection. The HKA test is particularly useful for detecting selection in genome-wide surveys because it uses relative comparisons across loci rather than requiring external calibration.