השוואת שיטות

	תאוריית הקואלסנציה	מבחן HKA
תחום	גנטיקה	גנטיקה
משפחה	Process / pipeline	Process / pipeline
שנת המקור	1982	1987
הוגה השיטה	John Kingman	Richard Hudson, Martin Kreitman & Montserrat Aguade
סוג	Stochastic process model	Statistical test
מקור מכונן	Kingman, J. F. C. (1982). The coalescent. Stochastic Processes and their Applications, 13(3), 235–248.	Hudson, R. R., Kreitman, M., & Aguadé, M. (1987). A test of neutral molecular evolution based on nucleotide data. Genetics, 116(1), 153–159.
כינויים	Kingman Coalescent, n-coalescent	HKA test, Polymorphism divergence test
קשורות	4	4
תקציר	Coalescent theory is a probabilistic framework that traces the genealogical history of DNA sequences backward in time to their most recent common ancestor. Developed by John Kingman in 1982, this method forms the foundation of modern population genetics, enabling researchers to understand demographic events, estimate genetic parameters, and reconstruct evolutionary histories from modern genetic data.	The Hudson-Kreitman-Aguade (HKA) test is a statistical method that tests for neutral evolution by comparing levels of within-population polymorphism and between-population divergence at multiple loci. Developed by Hudson, Kreitman, and Aguade in 1987, this test uses the principle that neutral loci should show expected relationships between polymorphism and divergence. Loci deviating from these relationships are candidates for selection. The HKA test is particularly useful for detecting selection in genome-wide surveys because it uses relative comparisons across loci rather than requiring external calibration.