Comparer des méthodes

	Gonflement et dégradation	Analyse Mécanique Dynamique
Domaine	Biomatériaux	Biomatériaux
Famille	Process / pipeline	Process / pipeline
Année d'origine	1960	1960
Auteur d'origine	Wichterle and Lim	Ferry and Schwarzl
Type	Kinetic assay	Rheological characterization
Source fondatrice	Wichterle, O., & Lim, D. (1960). Hydrophilic gels for biological use. Nature, 185(4706), 117-118.	Menard, K. P. (2008). Dynamic mechanical analysis: a practical introduction (2nd ed.). CRC Press.
Alias	hydrogel swelling, polymer degradation, mass loss assay	DMA, rheological analysis, viscoelastic testing
Apparentées	4	3
Résumé	The swelling and degradation assay measures how biomaterial scaffolds absorb water (swelling) and lose mass over time due to degradation. Developed by Wichterle and Lim in 1960 for hydrogels, the assay is fundamental for characterizing hydrogels, synthetic polymers, and composite scaffolds intended for tissue engineering. The assay provides quantitative data on swelling kinetics (equilibrium water content, swelling ratio), degradation kinetics (mass loss rate, half-life), and mechanisms of degradation (chain scission, enzymatic breakdown).	Dynamic mechanical analysis (DMA) measures the viscoelastic properties of materials—their elastic stiffness and viscous damping—by applying a sinusoidal stress or strain and measuring the phase lag and amplitude of the material's response. Developed from rheology principles in the 1960s and formalized by Ferry, Schwarzl, and others, DMA provides quantitative measures of how polymeric biomaterials respond to time-dependent and frequency-dependent mechanical stimuli. Key outputs include the storage modulus (elastic component), loss modulus (viscous component), and loss tangent (tan δ), which together characterize the material's mechanical behavior across temperature and frequency ranges.