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| Analyse de Schild× | Cinétique de Michaelis-Menten× | |
|---|---|---|
| Domaine | Pharmacologie | Pharmacologie |
| Famille | Process / pipeline | Process / pipeline |
| Année d'origine≠ | 1947 | 1913 |
| Auteur d'origine≠ | Henry Schild | Leonor Michaelis and Maud Menten |
| Type≠ | antagonism quantification | mechanistic model |
| Source fondatrice≠ | Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357. DOI ↗ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ |
| Alias≠ | Schild plot, pA2 | MM kinetics, Michaelis constant, Vmax |
| Apparentées≠ | 3 | 2 |
| Résumé≠ | Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems. | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. |
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