Comparer des méthodes

	Conception de plans Box-Behnken basée sur les risques	Planification d'Expériences
Domaine	Plans d'expériences	Plans d'expériences
Famille	Process / pipeline	Process / pipeline
Année d'origine	2005–2009 (QbD-era integration of risk assessment with BBD)	1935
Auteur d'origine	Box & Behnken (BBD, 1960); risk integration formalized under ICH Q8/Q9 pharmaceutical QbD frameworks (~2005–2009)	Ronald A. Fisher
Type	Response surface experimental design with risk prioritization	Experimental planning framework
Source fondatrice	Box, G. E. P., & Behnken, D. W. (1960). Some new three level designs for the study of quantitative variables. Technometrics, 2(4), 455–475.	Fisher, R. A. (1935). The Design of Experiments. Oliver and Boyd.
Alias	Risk-based BBD, Risk-prioritized Box-Behnken, QbD Box-Behnken design, Risk-informed RSM	DOE, experimental design, factorial experimentation, planned experimentation
Apparentées	4	3
Résumé	Risk-based Box-Behnken Design combines the classical three-level Box-Behnken response surface design with a formal risk assessment step — typically a risk ranking tool such as FMEA or Ishikawa analysis — to prioritize which process or formulation factors deserve experimental investigation. Widely adopted in pharmaceutical Quality by Design (QbD) and engineering process optimization, the approach ensures that experimental resources are directed toward the factor combinations most likely to affect product quality or process performance, reducing unnecessary runs while preserving predictive power.	Design of Experiments (DOE) is a systematic framework for planning, conducting, and analyzing controlled experiments to determine how multiple input factors simultaneously affect one or more responses. Introduced by Ronald A. Fisher in 1935, DOE allows researchers and engineers to identify causal relationships, quantify factor effects, and find optimal settings efficiently — using far fewer runs than one-factor-at-a-time approaches. It is foundational in engineering, manufacturing, agriculture, and applied sciences.