Comparer des méthodes

	MSFC : Multiple Sclerosis Functional Composite	Échelle étendue de statut d'incapacité de Kurtzke (EDSS)
Domaine	Neurologie	Neurologie
Famille	Process / pipeline	Process / pipeline
Année d'origine	1999	1983
Auteur d'origine	Gary Cutter, Richard Rudick, and NMSS Consortium	John F. Kurtzke
Type	Clinician-administered performance test	Clinician-rated
Source fondatrice	Cutter, G. R., Baier, M. L., Rudick, R. A., et al. (1999). Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Multiple Sclerosis, 5(4), 244-250.	Kurtzke, J. F. (1983). Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology, 33(11), 1444-1452.
Alias	MS Functional Composite	Expanded Disability Status Scale
Apparentées	4	4
Résumé	The Multiple Sclerosis Functional Composite (MSFC) is an objective, performance-based assessment of MS-related disability capturing three key functional domains: lower extremity mobility, upper extremity coordination, and cognitive/processing speed. Developed in 1999 by the National MS Society and adopted widely in clinical trials, the MSFC provides quantifiable endpoints complementing the Expanded Disability Status Scale (EDSS). The three-component design addresses EDSS limitations by including cognition and standardizing measurement via timed tasks.	The EDSS is the most widely used clinical disability rating scale in multiple sclerosis research and practice. Developed by John Kurtzke in 1983, it provides a 0-10 ordinal scale capturing disease severity across eight neurological functional systems and functional status. The EDSS remains the primary endpoint in MS clinical trials and longitudinal cohort studies, with decades of prognostic and comparative data worldwide.