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| Analyse isobolographique× | Cinétique de Michaelis-Menten× | |
|---|---|---|
| Domaine | Pharmacologie | Pharmacologie |
| Famille | Process / pipeline | Process / pipeline |
| Année d'origine≠ | 1926 | 1913 |
| Auteur d'origine≠ | Salvatore Loewe | Leonor Michaelis and Maud Menten |
| Type≠ | synergy quantification | mechanistic model |
| Source fondatrice≠ | Loewe, S. (1926). Die Mischtoxizität. Zeitschrift für Experimentelle Pathologie und Therapie, 24, 315-334. link ↗ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ |
| Alias | isobol, combination index, synergy testing | MM kinetics, Michaelis constant, Vmax |
| Apparentées≠ | 3 | 2 |
| Résumé≠ | Isobologram analysis is a graphical and quantitative method for detecting and classifying drug interactions, developed by Salvatore Loewe in 1926. It uses dose-response data from two drugs applied individually and in combination to determine whether their interaction is additive, synergistic, or antagonistic. | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. |
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