Comparer des méthodes

	Cohérence unitaire hétéronucléaire par champ pulsé (HSQC)	Spectrométrie de masse par transformée de Fourier à cyclotron ionique (FT-ICR)
Domaine	Spectroscopie	Spectroscopie
Famille	Process / pipeline	Process / pipeline
Année d'origine	1980	1974
Auteur d'origine	Anil Kumar	Alan Marshall
Type	Heteronuclear correlation sequence	Mass spectrometry technique
Source fondatrice	Bodenhausen, G., & Ruben, D. J. (1981). Natural abundance nitrogen-15 NMR by enhanced heteronuclear spectroscopy. Chemical Physics Letters, 69(2), 185-189.	Comisarow, M. B., & Marshall, A. G. (1974). Fourier transform ion cyclotron resonance spectroscopy. Chemical Physics Letters, 25(2), 282-283.
Alias	HSQC NMR, 1H-13C HSQC, heteronuclear correlation	FT-ICR-MS, Fourier Transform ICR, ICR mass spectrometry
Apparentées	4	4
Résumé	Heteronuclear Single-Quantum Coherence (HSQC) is a 2D NMR technique that correlates proton and carbon-13 (or other heteronuclei) chemical shifts through one-bond coupling constants (1JHX). Developed in the early 1980s, HSQC rapidly became the workhorse of structural chemistry because it directly maps which carbons bear which protons, providing a comprehensive view of carbon skeleton connectivity and substitution patterns.	Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometry is an advanced analytical technique that combines magnetic confinement of ions with Fourier transform data processing to achieve exceptional mass accuracy and resolution. Developed by Comisarow and Marshall in 1974, FT-ICR-MS enables the determination of exact masses and elemental compositions of complex molecules, making it invaluable for environmental chemistry, metabolomics, petroleum characterization, and structural elucidation of unknowns.