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| Méthode de Chou-Talalay× | Analyse de Schild× | |
|---|---|---|
| Domaine | Pharmacologie | Pharmacologie |
| Famille | Process / pipeline | Process / pipeline |
| Année d'origine≠ | 1983 | 1947 |
| Auteur d'origine≠ | Ting-Chao Chou and Paul Talalay | Henry Schild |
| Type≠ | synergy quantification | antagonism quantification |
| Source fondatrice≠ | Chou, T. C., & Talalay, P. (1983). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances in Enzyme Regulation, 22, 27-55. DOI ↗ | Schild, H. O. (1947). pA, a new scale for the measurement of drug antagonism. Journal of Physiology, 106(3), 337-357. DOI ↗ |
| Alias≠ | CI method, Chou method, median-effect analysis | Schild plot, pA2 |
| Apparentées | 3 | 3 |
| Résumé≠ | The Chou-Talalay method is a quantitative framework for analyzing drug interactions, developed by Ting-Chao Chou and Paul Talalay in 1983. It combines median-effect principle with the combination index (CI) to provide rigorous, model-independent assessment of synergistic, additive, or antagonistic drug effects. | Schild analysis is a quantitative method for characterizing competitive receptor antagonism developed by Henry Schild in 1947. It uses dose-response curves in the presence and absence of antagonist to estimate the antagonist affinity constant (pA2), enabling standardized comparison of antagonist potency across drugs and experimental systems. |
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