Vertaile menetelmiä

	Annos-vaste -kokeellinen suunnittelu ja analyysi	Logistinen regressio
Tieteenala	Koesuunnittelu	Tutkimuksen tilastomenetelmät
Menetelmäperhe	Hypothesis test	Process / pipeline
Syntyvuosi	1994	1958
Kehittäjä	Classical pharmacology; formalized by ICH E4 (1994) and Ritz et al. (2015)	David Roxbee Cox
Tyyppi	Nonlinear curve fitting and monotone contrast testing	Method
Alkuperäislähde	Ritz, C., Baty, F., Streibig, J. C., & Gerhard, D. (2015). Dose-Response Analysis Using R. PLOS ONE, 10(12), e0146021.	Cox, D. R. (1958). The regression analysis of binary sequences. Journal of the Royal Statistical Society, Series B, 20(2), 215–242.
Rinnakkaisnimet	dose-response analysis, dose-response curve, Doz-Yanıt Tasarımı ve Analizi (Dose-Response), ED50 analysis	logit model, binomial logistic regression, LR
Liittyvät	4	3
Tiivistelmä	Dose-response design is a framework for planning and analysing experiments that characterise the relationship between the amount of a stimulus — such as a drug dose or a chemical concentration — and the magnitude of a biological or physiological response. Formalised in regulatory guidance by the ICH E4 guideline (1994) and extensively developed in the statistical literature by Ritz et al. (2015), the framework covers experiment design, four-parameter and five-parameter logistic curve fitting, key benchmark estimates (ED50/EC50, NOAEL, LOAEL), and monotone trend testing via the Williams procedure.	Logistic regression is a statistical method for modeling the probability of a binary outcome (disease present/absent, success/failure) as a function of continuous and categorical predictors. Developed by David Roxbee Cox (1958), it solves the problem of predicting categorical outcomes by applying a logistic transformation to constrain predictions to the [0,1] probability interval, enabling accurate risk stratification, diagnostic prediction, and causal inference in epidemiology, medicine, and social science.