Risk-adjusted screening test evaluation
Risk-adjusted screening test evaluation assesses the sensitivity, specificity, and overall discriminatory accuracy of a screening test after accounting for patient-level risk factors (covariates) that independently influence test results or disease prevalence. By conditioning performance metrics on observed covariates — age, sex, comorbidities, or prior screening history — this approach yields accuracy estimates that are not confounded by differences in population risk profiles, enabling fair comparisons across subgroups or study settings.
Allikakirje
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- Pepe, M. S. (2003). The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford University Press. · ISBN 978-0198565826
- Janes, H., & Pepe, M. S. (2009). Adjusting for covariate effects on classification accuracy using the covariate-adjusted ROC curve. Biometrika, 96(2), 371–382. · DOI 10.1093/biomet/asp002
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