Comparar métodos

	Diseño experimental híbrido	Metodología de Superficie de Respuesta (RSM)
Campo	Diseño experimental	Diseño experimental
Familia	Process / pipeline	Hypothesis test
Año de origen	1989–2000s	1951
Autor original	Multiple contributors; notably Sacks, Welch, Mitchell & Wynn (computer experiments); broader hybrid concept developed across 1980s–2000s	George E. P. Box & K. B. Wilson
Tipo	Combined experimental design strategy	Second-order polynomial response surface model
Fuente seminal	Santner, T. J., Williams, B. J., & Notz, W. I. (2003). The Design and Analysis of Computer Experiments. Springer. ISBN: 978-1441929921	Box, G. E. P. & Wilson, K. B. (1951). On the experimental attainment of optimum conditions. Journal of the Royal Statistical Society, Series B, 13(1), 1–45.
Alias	hybrid DOE, combined experimental design, mixed experimental design, hybrid experimental strategy	RSM, Central Composite Design, Box-Behnken Design, CCD
Relacionados	4	7
Resumen	Hybrid design of experiments (hybrid DOE) combines two or more experimental design strategies within a single study to exploit the complementary strengths of each. Common combinations include factorial or fractional-factorial arrays paired with computer simulation runs, space-filling Latin hypercube designs merged with response surface augmentations, or Taguchi orthogonal arrays integrated with response surface methodology. The approach is widely used when a single design type cannot efficiently cover all phases of an engineering investigation — from screening through to optimization.	Response Surface Methodology is a collection of statistical and mathematical techniques for building an empirical second-order polynomial model that relates a continuous response variable to two or more controllable input factors, and then locating the factor settings that optimize that response. The approach was introduced by George E. P. Box and K. B. Wilson in their landmark 1951 paper and has since become a cornerstone of process optimization across engineering, chemistry, food science, and pharmaceutics.