Process / pipelinePharmacodynamics
Chou-Talalay Method
The Chou-Talalay method is a quantitative framework for analyzing drug interactions, developed by Ting-Chao Chou and Paul Talalay in 1983. It combines median-effect principle with the combination index (CI) to provide rigorous, model-independent assessment of synergistic, additive, or antagonistic drug effects.
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Sources
- Chou, T. C., & Talalay, P. (1983). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances in Enzyme Regulation, 22, 27-55. DOI: 10.1016/0065-2571(84)90013-3 ↗
- Chou, T. C. (1986). Quantitative analysis of the dose-effect relationship. Life Sciences, 38(26), 2347-2358. DOI: 10.1016/0024-3205(86)90374-5 ↗