Process / pipelinedisease-specific symptom burden
Non-Motor Symptoms Scale for Parkinson's Disease (NMSS)
The NMSS is a comprehensive 30-item scale designed to assess the prevalence and impact of non-motor symptoms (NMS) in Parkinson's disease. Developed by Chaudhuri and colleagues in 2007, it addresses the reality that non-motor features—sleep disorders, mood disturbances, autonomic dysfunction, cognitive impairment, and pain—often cause greater disability and suffering than motor symptoms in many PD patients. The scale is essential for comprehensive PD assessment and is increasingly recognized as a critical outcome measure reflecting true patient burden.
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Sources
- Chaudhuri, K. R., Martinez-Martin, P., Brown, R. G., Sethi, K., Stocchi, F., Odin, P., Ondo, W., Whone, A., Rye, D., Bhattacharya, K., Naidu, Y., Schapira, A. H., Brozova, H., Nutt, J., Macphee, G., Carroll, C., Hilten, J. V., Verschuuren, J., & Bonuccelli, U. (2007). The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study. Movement Disorders, 22(13), 1901-1911. DOI: 10.1002/mds.21596 ↗