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Target-Mediated Drug Disposition/Evidence
Method evidence record

Target-Mediated Drug Disposition

Target-mediated drug disposition (TMDD) is a mechanistic framework describing nonlinear pharmacokinetics arising from drug binding to a target receptor or protein. Developed by Mager and Jusko in 2001, TMDD explains saturable clearance, dose-dependent half-lives, and time-dependent changes in plasma concentrations observed with protein therapeutics and some small-molecule drugs.

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Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Target-Mediated Drug Disposition (TMDD)
Taxonomic method record · process-pipeline / pharmacology
  • Mager, D. E., & Jusko, W. J. (2001). General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Journal of Pharmacokinetics and Pharmacodynamics, 28(6), 507-532. · DOI 10.1023/A:1014414520282
  • Levy, G. (2004). Carrier-mediated active transport: pharmacokinetic consequences and examples in humans. Clinical Pharmacokinetics, 37(6), 429-445. · URL
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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Same method familyMichaelis-Menten Kineticsmachine-suggested · Relational suggestion, not evidence.Same method familyPhysiologically Based Pharmacokineticsmachine-suggested · Relational suggestion, not evidence.Same method familyPopulation Pharmacodynamicsmachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

2 recorded citations, copied from the method source record.

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