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Single-cell eQTL analysis/Evidence
Method evidence record

Single-cell eQTL analysis

Single-cell eQTL analysis identifies genetic variants (eQTLs) that regulate gene expression in a cell-type-specific manner by jointly analysing single-cell RNA-seq profiles and donor genotype data. Unlike bulk eQTL methods, it resolves regulatory effects that are diluted or masked when cell types are mixed, enabling discovery of variants whose effects are confined to particular cell states or developmental stages.

Sources recorded, not reviewed

Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Single-cell Expression Quantitative Trait Loci Analysis
Taxonomic method record · process-pipeline / bioinformatics
  • Cuomo, A. S. E., et al. (2020). Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression. Nature Communications, 11(1), 810. · URL
  • Kim-Hellmuth, S., et al. (2020). Cell type–specific genetic regulation of gene expression across human tissues. Science, 369(6509), eaaz8528. · URL
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Curated claims

Claims persisted in the evidence ledger, each with its own assessment.

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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Taxonomic bucketeQTL Analysismachine-suggested · Relational suggestion, not evidence.Taxonomic bucketGenome-wide association studymachine-suggested · Relational suggestion, not evidence.Taxonomic bucketPathway Enrichment Analysismachine-suggested · Relational suggestion, not evidence.Taxonomic bucketRNA-seq Differential Expressionmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell GWASmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketSingle-cell RNA-seq analysismachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

2 recorded citations, copied from the method source record.

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