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Retrospective phase II clinical trial/Evidence
Method evidence record

Retrospective phase II clinical trial

A retrospective Phase II clinical trial evaluates a treatment's preliminary efficacy and safety signals using existing archival data — medical records, registries, or electronic health records — rather than prospectively enrolling new patients. It mirrors the objectives of a standard Phase II trial (estimating response rate, tolerability, and early efficacy) but does so by looking backward at patients who have already received the intervention, making it faster and less costly than a prospective design.

Sources recorded, not reviewed

Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Retrospective Phase II Clinical Trial
Taxonomic method record · process-pipeline / epidemiology
  • Simon, R. (1989). Optimal two-stage designs for phase II clinical trials. Controlled Clinical Trials, 10(1), 1–10. · DOI 10.1016/0197-2456(89)90015-9
  • Clinical trial. Wikipedia. · URL
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Curated claims

Claims persisted in the evidence ledger, each with its own assessment.

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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Same method familyDiagnostic Accuracy Study Designmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketPhase I Clinical Trialmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketPhase II clinical trialmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketPhase III clinical trialmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketRetrospective Cohort Studymachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

2 recorded citations, copied from the method source record.

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