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Pharmacophore Modeling/Evidence
Method evidence record

Pharmacophore Modeling

Pharmacophore modeling identifies the spatial arrangement of molecular features (hydrogen bond donors, acceptors, aromatic rings) that are essential for biological activity. Introduced by Gund in 1977, this ligand-based method creates a three-dimensional pattern that can screen chemical libraries and design new active compounds without requiring receptor structure.

Sources recorded, not reviewed

Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Pharmacophore-based Ligand Design and Virtual Screening
Taxonomic method record · process-pipeline / bioinformatics
  • Wermuth, C. G., Ganellin, C. R., Lindberg, P., & Mitscher, L. A. (1998). Glossary of terms used in medicinal chemistry. Pure and Applied Chemistry, 70(5), 1129-1143. · DOI 10.1351/pac199870051129
  • Ohno, K. & Ueda, Y. (2006). Modern photochemistry of organic compounds. Wiley & Sons. · URL
  • Leung, S. C., Bodkin, M., von Delft, F., & Morris, G. M. (2012). SiteMap: a tool for identifying and characterizing binding sites in protein structures. Journal of Chemical Information and Modeling, 52(11), 3008-3020. · URL
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Curated claims

Claims persisted in the evidence ledger, each with its own assessment.

No curated claims yet

This view does not invent a claim assessment when the ledger has none.

Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Same method familyHomology Modelingmachine-suggested · Relational suggestion, not evidence.Same method familyMolecular Dockingmachine-suggested · Relational suggestion, not evidence.Same method familyQSARmachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

3 recorded citations, copied from the method source record.

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