Method evidence record

Multicenter Cox proportional hazards

Multicenter Cox proportional hazards regression extends the classic Cox PH model to studies conducted at two or more clinical sites or centers. It estimates the effect of predictors on time-to-event outcomes while explicitly accounting for clustering within centers, between-center heterogeneity, and potential differences in baseline hazard across sites. This design is standard practice in large multicenter RCTs and observational cohort studies in oncology, cardiology, and other clinical fields.

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Multicenter Cox Proportional Hazards Regression

Taxonomic method record · process-pipeline / epidemiology

Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202. · DOI 10.1111/j.2517-6161.1972.tb00899.x
Therneau, T. M., & Grambsch, P. M. (2000). Modeling Survival Data: Extending the Cox Model. Springer. · ISBN 978-0387987842

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Related methods

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Taxonomic bucketCox proportional hazardsmachine-suggested · Relational suggestion, not evidence.Taxonomic bucketKaplan-Meier Analysismachine-suggested · Relational suggestion, not evidence.Taxonomic bucketMulticenter cohort studymachine-suggested · Relational suggestion, not evidence.Same method familySurvival Analysismachine-suggested · Relational suggestion, not evidence.