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Dose-Escalation Design/Evidence
Method evidence record

Dose-Escalation Design

Dose-Escalation Design, formalized as the Continual Reassessment Method (CRM), is a Bayesian adaptive algorithm for identifying the Maximum Tolerated Dose (MTD) in Phase I clinical trials. Introduced by John O'Quigley, Margaret Pepe, and Lloyd Fisher in 1990, CRM treats dose-toxicity response as a parametric curve, updates a prior probability model after each patient's outcome, and assigns subsequent patients to the dose currently estimated closest to a pre-specified target toxicity probability.

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Dose-Escalation Design (Continual Reassessment Method)
Taxonomic method record · process-pipeline / experimental-design
  • O'Quigley, J., Pepe, M., & Fisher, L. (1990). Continual reassessment method: a practical design for phase 1 clinical trials in cancer. Biometrics, 46(1), 33–48. · DOI 10.2307/2531628
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Related methods

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See alsoBayesian Inferencemachine-suggested · Relational suggestion, not evidence.Used in the same domainSequential Designmachine-suggested · Relational suggestion, not evidence.

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1 recorded citation, copied from the method source record.

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