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Case-crossover design/Evidence
Method evidence record

Case-crossover design

The case-crossover design is an observational epidemiological method that estimates whether a transient exposure triggers an acute event by comparing each case's exposure during a brief hazard window immediately before the event to their own exposure during earlier control periods. Because each person serves as their own control, all stable personal characteristics are automatically adjusted for, making the design especially powerful for studying intermittent exposures and sudden-onset outcomes such as myocardial infarction, stroke, or injury.

Sources recorded, not reviewed

Source record

Citations copied verbatim from the method’s source record. No claim-level verification is inferred from them.

Case-Crossover Study Design
Taxonomic method record · process-pipeline / epidemiology
  • Maclure, M. (1991). The case-crossover design: A method for studying transient effects on the risk of acute events. American Journal of Epidemiology, 133(2), 144–153. · DOI 10.1093/oxfordjournals.aje.a115853
  • Mittleman, M. A., Maclure, M., & Robins, J. M. (1995). Control sampling strategies for case-crossover studies: An assessment of relative efficiency. American Journal of Epidemiology, 142(1), 91–98. · DOI 10.1093/oxfordjournals.aje.a117550
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Curated claims

Claims persisted in the evidence ledger, each with its own assessment.

No curated claims yet

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Related methods

Generated from the method graph and shown as machine-suggested relations — no evidence claim is inferred.

Taxonomic bucketCase-control studymachine-suggested · Relational suggestion, not evidence.Taxonomic bucketCohort Studymachine-suggested · Relational suggestion, not evidence.Taxonomic bucketNested case-controlmachine-suggested · Relational suggestion, not evidence.Same method familySelf-Controlled Case Seriesmachine-suggested · Relational suggestion, not evidence.

Evidence status

Sources recorded, not reviewed

Bibliographic sources are present. Claim-level evidence review has not been performed.

Sources

2 recorded citations, copied from the method source record.

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