Process / pipelineClinical / epidemiology
Multicenter Case Series — Multi-Site Descriptive Clinical Study
A multicenter case series is an observational descriptive study in which consecutive or selected patients sharing a defined clinical condition are enrolled and followed at two or more independent clinical sites. By pooling cases across institutions, researchers achieve larger sample sizes and greater demographic and clinical diversity than a single-center series permits, enabling more reliable description of disease presentation, management patterns, and outcomes for rare or uncommon conditions.
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Sources
- Dekkers, O. M., Vandenbroucke, J. P., Cevallos, M., Renehan, A. G., Altman, D. G., & Egger, M. (2012). COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology and prognosis. PLoS Medicine, 9(2), e1001175. DOI: 10.1371/journal.pmed.1001175 ↗
- Matthews, J. N. S. (2006). Introduction to Randomized Controlled Clinical Trials (2nd ed.). Chapman and Hall/CRC. ISBN: 978-1584886242