Multi-omics Phylogenetic Analysis — Integrative Phylogenomics

Multi-omics phylogenetic analysis reconstructs evolutionary relationships among organisms by integrating sequence data from multiple molecular layers — genomes, transcriptomes, and proteomes — rather than relying on a single marker gene. By combining thousands of orthologous loci across omics layers, the approach dramatically reduces stochastic error, resolves ancient divergences that single-gene trees cannot, and yields a far more robust and well-supported topology of the tree of life or a focal clade.