Process / pipelineBioinformatics / omics
Bayesian GWAS — Bayesian Genome-Wide Association Study
Bayesian GWAS applies Bayesian statistical inference to genome-wide association studies, replacing classical p-value thresholds with Bayes factors and posterior probabilities. This framework naturally incorporates prior knowledge about effect sizes and variant frequencies, quantifies evidence for association on a continuous scale, and supports principled fine-mapping of causal variants within associated loci. It is widely used in complex trait genetics, population genomics, and translational research where uncertainty quantification and multi-variant modeling matter.
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Sources
- Stephens, M., & Balding, D. J. (2009). Bayesian statistical methods for genetic association studies. Nature Reviews Genetics, 10(10), 681–690. DOI: 10.1038/nrg2615 ↗
- Wakefield, J. (2009). Bayes factors for genome-wide association studies: comparison with P-values. Genetic Epidemiology, 33(1), 79–86. DOI: 10.1002/gepi.20359 ↗