Methoden vergleichen

	Pragmatische Überlebenszeitanalyse	Cox-Proportional-Hazards-Modell
Fachgebiet	Epidemiologie	Epidemiologie
Familie	Process / pipeline	Process / pipeline
Entstehungsjahr	Conceptual framework: 1967; widespread application: 1990s–2000s	1972
Urheber	Schwartz & Lellouch (explanatory vs. pragmatic distinction, 1967); extended in survival analysis literature from the 1970s onward	Sir David Roxbee Cox
Typ	Observational / experimental hybrid — time-to-event analysis in real-world or pragmatic-trial settings	Semi-parametric regression model
Wegweisende Quelle	Ford, I., & Norrie, J. (2016). Pragmatic Trials. New England Journal of Medicine, 375(5), 454–463.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
Aliasnamen	real-world survival analysis, pragmatic time-to-event analysis, effectiveness survival analysis, PSA	Cox regression, Cox PH model, proportional hazards model, CPH
Verwandt	5	5
Zusammenfassung	Pragmatic survival analysis applies time-to-event statistical methods within pragmatic or real-world settings, estimating how long patients survive, remain event-free, or retain treatment benefit under conditions of routine clinical practice. Unlike explanatory survival analyses conducted under tightly controlled trial conditions, the pragmatic variant embraces the heterogeneity, treatment switching, non-adherence, and competing events that characterise real-world patient populations, prioritising external validity over internal precision.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.