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| Multizentrische Screening-Test-Evaluierung× | Studiendesign zur diagnostischen Genauigkeit× | |
|---|---|---|
| Fachgebiet≠ | Epidemiologie | Klinische Forschung |
| Familie | Process / pipeline | Process / pipeline |
| Entstehungsjahr≠ | 1976–2003 (core diagnostic accuracy framework; multicenter STARD standards formalized 2003) | 2003-2015 |
| Urheber≠ | Methodological consensus (STARD group, Bossuyt et al.); broader diagnostic accuracy tradition rooted in Hanley & McNeil (1982) and Sackett & Haynes (1976) | Bossuyt, Reitsma, and STARD group (2003); clinical epidemiology pioneers |
| Typ≠ | Observational diagnostic accuracy study | Research Design |
| Wegweisende Quelle≠ | Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., Lijmer, J. G., Moher, D., Rennie, D., & de Vet, H. C. W. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Annals of Internal Medicine, 138(1), 40-44. DOI ↗ | Bossuyt, P. M., Reitsma, J. B., Bruns, D. E., Gatsonis, C. A., Glasziou, P. P., Irwig, L. M., ... & de Vet, H. C. (2003). Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. Annals of Internal Medicine, 138(1), 40–44. DOI ↗ |
| Aliasnamen | multicenter diagnostic accuracy study, multisite screening evaluation, multicenter test performance study, multicenter DTA study | diagnostic accuracy study, test accuracy, STARD, diagnostic evaluation |
| Verwandt≠ | 6 | 2 |
| Zusammenfassung≠ | A multicenter screening test evaluation measures the diagnostic accuracy of a screening test — its sensitivity, specificity, predictive values, and ROC-curve area — by enrolling participants across two or more independent clinical sites. Conducting the study at multiple centers broadens the patient spectrum, tests generalizability across different laboratory conditions and patient populations, and produces more externally valid accuracy estimates than a single-center study. | A diagnostic accuracy study evaluates how well a new diagnostic test (or biomarker, imaging modality, clinical assessment) detects the presence or absence of disease compared to a reference standard (gold standard). Standardized since 2003 by the STARD (Standards for Reporting of Diagnostic Accuracy Studies) initiative, diagnostic accuracy studies are fundamental to clinical medicine, determining whether and how new tests can improve patient diagnosis and treatment. |
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