Methoden vergleichen

	Multicenter Cox proportional hazards	Cox-Proportional-Hazards-Modell
Fachgebiet	Epidemiologie	Epidemiologie
Familie	Process / pipeline	Process / pipeline
Entstehungsjahr	1972 (Cox model); multicenter applications formalized 1980s–1990s	1972
Urheber	D. R. Cox (Cox PH model); multicenter extension developed through collaborative trial methodology	Sir David Roxbee Cox
Typ	Semi-parametric survival regression for clustered data	Semi-parametric regression model
Wegweisende Quelle	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.	Cox, D. R. (1972). Regression models and life-tables. Journal of the Royal Statistical Society: Series B (Methodological), 34(2), 187–202.
Aliasnamen	multicenter Cox regression, multisite Cox PH model, stratified Cox model across centers, multicenter survival regression	Cox regression, Cox PH model, proportional hazards model, CPH
Verwandt	4	5
Zusammenfassung	Multicenter Cox proportional hazards regression extends the classic Cox PH model to studies conducted at two or more clinical sites or centers. It estimates the effect of predictors on time-to-event outcomes while explicitly accounting for clustering within centers, between-center heterogeneity, and potential differences in baseline hazard across sites. This design is standard practice in large multicenter RCTs and observational cohort studies in oncology, cardiology, and other clinical fields.	The Cox proportional hazards model is a semi-parametric regression method that estimates the effect of one or more covariates on the hazard — the instantaneous rate of an event such as death, relapse, or failure — while making no assumption about the shape of the baseline hazard function. Introduced by David Cox in 1972, it is the dominant tool for multivariable survival analysis in clinical and epidemiological research.