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| Marginales Strukturelles Modell (MSM)× | G-Computation (Parametrische G-Formel)× | |
|---|---|---|
| Fachgebiet | Kausale Inferenz | Kausale Inferenz |
| Familie | Regression model | Regression model |
| Entstehungsjahr≠ | 2000 | 1986 |
| Urheber≠ | James M. Robins, Miguel A. Hernan, Babette Brumback | James M. Robins |
| Typ≠ | Causal model / semiparametric weighting | Parametric causal effect estimation |
| Wegweisende Quelle≠ | Robins, J. M., Hernan, M. A., & Brumback, B. (2000). Marginal structural models and causal inference in epidemiology. Epidemiology, 11(5), 550-560. DOI ↗ | Robins, J. M. (1986). A new approach to causal inference in mortality studies with sustained exposure periods: application to control of the healthy worker survivor effect. Mathematical Modelling, 7(9-12), 1393-1512. DOI ↗ |
| Aliasnamen≠ | MSM, MSM-IPTW, marginal structural Cox model, weighted structural model | G-formula, Parametric G-formula, Standardization |
| Verwandt≠ | 5 | 2 |
| Zusammenfassung≠ | A marginal structural model is a causal modeling framework designed to estimate the effect of a time-varying treatment in the presence of time-varying confounders that are themselves affected by prior treatment. By reweighting observations with inverse probability of treatment weights, MSMs create a pseudo-population in which confounding is eliminated, enabling unbiased estimation of causal treatment contrasts even when standard regression adjustments would fail. | G-computation is a causal inference method for estimating the effect of an intervention or treatment on an outcome from observational data. Developed by James M. Robins in 1986, it provides a parametric approach to standardization that can handle time-varying exposures and confounders. The method estimates what the population outcome would be under different intervention scenarios by utilizing fitted outcome models. |
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