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| Tidsrække-baseret pathway-anringsanalyse× | Pathway Enrichment Analysis× | |
|---|---|---|
| Fagområde | Bioinformatik | Bioinformatik |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | 2005–2014 | 2003–2005 |
| Ophavsperson≠ | Bar-Joseph and colleagues (temporal gene expression); extended by Cheng, Bhatt et al. for pathway-level time-series inference | Mootha et al. (2003); systematised by Subramanian et al. (2005) |
| Type≠ | Functional enrichment analysis with temporal modeling | Statistical functional annotation method |
| Oprindelig kilde≠ | Ernst, J., Nau, G. J., & Bar-Joseph, Z. (2005). Clustering short time series gene expression data. Bioinformatics, 21(Suppl 1), i159–i168. link ↗ | Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., & Mesirov, J. P. (2005). Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545–15550. DOI ↗ |
| Aliasser | temporal pathway analysis, longitudinal pathway enrichment, dynamic pathway analysis, TPEA | PEA, overrepresentation analysis, ORA, functional enrichment analysis |
| Relaterede≠ | 5 | 6 |
| Resumé≠ | Time-series pathway enrichment analysis identifies biological pathways whose coordinated gene activity changes significantly across ordered time points. Rather than treating each time point independently, the method models the temporal trajectory of gene expression within each pathway and tests whether entire biological programs — not just individual genes — are activated or suppressed in a time-dependent manner. It is widely used in developmental biology, drug response studies, and infection time courses. | Pathway enrichment analysis (PEA) is a statistical approach that takes a list of genes or proteins of interest — typically derived from a differential expression or proteomics experiment — and identifies which pre-defined biological pathways or functional gene sets are represented more often than expected by chance. By mapping individual molecular changes onto curated pathway knowledge bases such as KEGG, Gene Ontology, or Reactome, PEA translates long gene lists into interpretable biological processes, making it a central tool in the post-analysis of high-throughput omics experiments. |
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