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| Michaelis-Menten-kinetik× | Populationsfarmakodynamisk modellering× | |
|---|---|---|
| Fagområde | Farmakologi | Farmakologi |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | 1913 | 1992 |
| Ophavsperson≠ | Leonor Michaelis and Maud Menten | Lewis Sheiner and Stephen Roush |
| Type≠ | mechanistic model | dose-response modeling |
| Oprindelig kilde≠ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ | Dahlström, B., & Nyberg, L. (1993). Population pharmacokinetics and pharmacodynamics. Clinical Pharmacokinetics, 24(1), 45-57. link ↗ |
| Aliasser | MM kinetics, Michaelis constant, Vmax | PopPD, population PD, hierarchical PD modeling |
| Relaterede≠ | 2 | 3 |
| Resumé≠ | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. | Population pharmacodynamic (PopPD) modeling integrates pharmacokinetics with individual dose-response relationships across patient populations to characterize drug efficacy and tolerability. Pioneered by Lewis Sheiner and colleagues, PopPD accounts for inter-individual variability in drug effects and enables rational dose optimization and response prediction. |
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