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| In Vitro-In Vivo Korrelation× | Michaelis-Menten-kinetik× | |
|---|---|---|
| Fagområde | Farmakologi | Farmakologi |
| Familie | Process / pipeline | Process / pipeline |
| Oprindelsesår≠ | 1995 | 1913 |
| Ophavsperson≠ | Gordon Amidon | Leonor Michaelis and Maud Menten |
| Type≠ | bioavailability prediction | mechanistic model |
| Oprindelig kilde≠ | Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413-420. DOI ↗ | Michaelis, L., & Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333-369. link ↗ |
| Aliasser≠ | IVIVC | MM kinetics, Michaelis constant, Vmax |
| Relaterede≠ | 3 | 2 |
| Resumé≠ | IVIVC is a mathematical relationship between in vitro and in vivo properties of a drug, developed to predict oral bioavailability from dissolution data. Introduced by Amidon and colleagues in the 1995 Biopharmaceutics Classification System, it bridges laboratory measurements and clinical outcomes to streamline drug development. | Michaelis-Menten kinetics describes the rate of enzyme-catalyzed reactions as a function of substrate concentration. Developed by Leonor Michaelis and Maud Menten in 1913, this foundational framework models enzyme catalysis through the rapid-equilibrium approximation and enables prediction of drug metabolism rates in pharmacokinetics. |
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