Porovnat metody
Prohlédněte si vybrané metody vedle sebe; řádky, které se liší, jsou zvýrazněny.
| Síťově orientovaná epigenomově-asociační studie (Network EWAS)× | Síťově orientovaná celogenomová asociační studie (Network-based GWAS)× | |
|---|---|---|
| Obor | Bioinformatika | Bioinformatika |
| Rodina | Process / pipeline | Process / pipeline |
| Rok vzniku≠ | 2010s, consolidating 2012–2018 | 2011–2013 (early tools); mature framework by 2015 |
| Tvůrce≠ | Adapted from EWAS (Rakyan et al., 2011) and network-based genomic methods (e.g., Ideker & Sharan, 2008) | Jia et al. (dmGWAS, 2011); Baranzini et al.; multiple concurrent groups |
| Typ≠ | Integrative epigenomic analysis | Network-augmented association analysis |
| Původní zdroj≠ | Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011). Epigenome-wide association studies for common human diseases. Nature Reviews Genetics, 12(8), 529–541. link ↗ | Wang, Q., Yu, H., Zhao, Z., & Jia, P. (2015). EW_dmGWAS: edge-weighted dense module search for genome-wide association studies and gene expression profiles. Bioinformatics, 31(15), 2591–2594. link ↗ |
| Další názvy | network EWAS, network-integrated EWAS, graph-based EWAS, network-based DNA methylation analysis | network GWAS, gene network GWAS, network-informed GWAS, NbGWAS |
| Příbuzné | 6 | 6 |
| Shrnutí≠ | Network-based EWAS extends conventional epigenome-wide association studies by overlaying differentially methylated positions or regions onto biological interaction networks — such as protein-protein interaction, co-expression, or gene regulatory networks — to identify functionally coherent epigenetic modules rather than isolated CpG hits. This integration increases statistical power for detecting weak signals and reveals coordinated epigenetic dysregulation across pathways. | Network-based GWAS integrates conventional genome-wide association study results with biological network data — such as protein-protein interaction (PPI) networks or gene co-expression graphs — to identify disease-relevant gene modules or subnetworks. Instead of reporting only the top individual SNPs, this approach propagates association signals through molecular interaction networks, surfacing gene clusters whose collective signal implicates them in complex-trait biology even when no single variant reaches genome-wide significance alone. |
| ScholarGateDatová sada ↗ |
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