Compara mètodes

	Assaig Clínic Aleatoritzat (RCT)	Estudi de Casos i Controls
Camp	Epidemiologia	Epidemiologia
Família	Process / pipeline	Process / pipeline
Any d'origen	1948 (first rigorously conducted RCT — MRC streptomycin trial)	1950s (formal methodology); precursors in the 1920s
Autor original	Austin Bradford Hill; MRC Streptomycin Trial team	Janet Lane-Claypon (early precursors, 1926); formalized by Brian MacMahon and Jerome Cornfield in the 1950s–1960s
Tipus	Interventional experimental study	Observational analytic study design
Font seminal	Friedman, L. M., Furberg, C. D., DeMets, D. L., Reboussin, D. M., & Granger, C. B. (2015). Fundamentals of Clinical Trials (5th ed.). Springer. ISBN: 978-3319185385	Schlesselman, J.J. (1982). Case-Control Studies: Design, Conduct, Analysis. Oxford University Press. ISBN: 978-0195027860
Àlies	RCT, randomized controlled trial, randomised controlled trial, clinical randomized trial	case-referent study, case-control design, retrospective case-control, case-control analysis
Relacionats	6	6
Resum	A randomized clinical trial (RCT) is an experimental study design in which participants are randomly assigned to an intervention group or a control group, then followed prospectively to compare outcomes. Random allocation is the defining feature: it distributes known and unknown confounders across groups by chance, making the RCT the strongest individual study design for establishing causal efficacy of a treatment or intervention under controlled conditions.	A case-control study is a retrospective observational design in which individuals who have developed a disease or outcome of interest (cases) are compared with individuals who have not (controls) to determine whether prior exposure to a putative risk factor differs between the two groups. The primary measure of association is the odds ratio, which approximates the relative risk when the outcome is rare. Case-control studies are especially efficient for investigating rare diseases and generating etiological hypotheses.