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| Modelatge per homologia× | Topologia de la Xarxa d'Interaccions Proteïna-Proteïna× | |
|---|---|---|
| Camp | Bioinformàtica | Bioinformàtica |
| Família | Process / pipeline | Process / pipeline |
| Any d'origen≠ | 1993 | 2000 |
| Autor original≠ | Andrej Sali | Peter Uetz |
| Tipus≠ | Comparative structure prediction pipeline | Network analysis pipeline |
| Font seminal≠ | Sali, A. & Blundell, T. L. (1993). Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology, 234(3), 779-815. DOI ↗ | Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., ... & Lomax, J. (2000). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature, 403(6770), 623-627. DOI ↗ |
| Àlies≠ | comparative modeling, template-based modeling | protein interaction networks, interactome analysis, network topology |
| Relacionats≠ | 4 | 3 |
| Resum≠ | Homology modeling, also called comparative modeling, predicts the three-dimensional structure of a protein using an experimentally-solved structure of a homologous protein as a template. Introduced by Sali and Blundell in 1993, this method exploits the principle that homologous proteins share similar spatial structures despite differing in amino acid sequence. | Protein-protein interaction network analysis identifies and characterizes the structural properties of cellular interaction networks. Pioneered by Uetz and colleagues through large-scale yeast two-hybrid screening, this approach reveals topological features like hubs, modules, and motifs that encode functional organization and disease associations. |
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